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Metformin is used to treat Type II Diabetes. It is excreted in the urine with no metabolism

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January 8th, 2018

Metformin is used to treat Type II Diabetes. It is excreted in the urine with no metabolism from the liver with a half-life of 5 hours. Average Volume of Distribution of Metformin is 654 L for a dose of 850 mg. If the plasma concentration of the drug needs to be at least 200 µg / L, how many times a day would an 850 mg dose need to be taken to maintain this concentration?I dont want just the answer. I want a little explanation too.

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