DNA STRUCTURE AND STABILITY WORKSHEET
2017 NAME:_____________________________________ DNA STRUCTURE AND STABILITY WORKSHEET1. Fill in the replicated DNA to indicate how the GT transversion occurred due to guanineadduct formation (the arrows indicate rounds of DNA replication; G is the adducted guanine): —– C—–G—— C–G— —–G —– —– —– 2. What kinds of Physical Carcinogens can cause GT transversions? How? 3. What kinds of Chemical carcinogens can cause GT transversions? How? 4. What DNA repair mechanisms or proteins can remove adducted guanine nucleotides? How? 5. Which DNA repair mechanism is BRCA1 involved in? What role does it play? 6. How do the platins (cisplatin, carboplatin) modify DNA bases? If left unrepaired, how dothese defects affect cancer cell? 7. Name an example of an antimetabolite. How do these compounds affect cancer cells? 8. What are the cellular targets of vinca alkaloids and taxanes? Do vinblastine and taxol havethe same or different effects on these targets?
